NS MMQ 2-site

The relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for MMQ CPMG-type data.

Parameters

The NS MMQ 2-site model has the parameters {$R_2^0$, $...$, $p_A$, $\Delta\omega$, $\Delta\omega^H$, $k_{ex}$}.

Reference

The references for the NS MMQ 2-site model are:

• Korzhnev, D. M., Kloiber, K., Kanelis, V., Tugarinov, V., and Kay, L. E. (2004). Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme. J. Am. Chem. Soc., 126(12), 3964-3973. (10.1021/ja039587i).
• Korzhnev, D. M., Kloiber, K., and Kay, L. E. (2004). Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application. J. Am. Chem. Soc., 126(23), 7320-7329. (10.1021/ja049968b).
• Korzhnev, D. M., Neudecker, P., Mittermaier, A., Orekhov, V. Y., and Kay, L. E. (2005). Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant. J. Am. Chem. Soc., 127(44), 15602-15611. (10.1021/ja054550e).

Links

The implementation of the NS MMQ 2-site model in relax can be seen in the:

• relax manual,
• API documentation,
• relaxation dispersion page of the relax website.