Difference between revisions of "NS MMQ 3-site linear"

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(→‎Intro: Link fix.)
(→‎See also: Added more categories.)
 
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= Intro =
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The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for [[:Category:MMQ CPMG data|MMQ CPMG-type data]] linearised with {{:kAC}} = {{:kCA}} = 0 whereby the simplification {{:R2Azero}} = {{:R2Bzero}} = {{:R2Czero}} is assumed.
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The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for [[:Category:MMQ CPMG data|MMQ CPMG-type data]] linearised with $k_{AC} = k_{CA} = 0$ whereby the simplification $R^0_{2A} = R^0_{2B} = R^0_{2C}$ is assumed.
 
  
 
== Parameters ==
 
== Parameters ==
  
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The NS MMQ 3-site linear model has the parameters {$R_2^0$, $...$, $p_A$, $p_B$, $\Delta\omega_{AB}$, $\Delta\omega_{BC}$, $\Delta\omega^H_{AB}$, $\Delta\omega^H_{BC}$, $k_{ex}^{AB}$, $k_{ex}^{BC}$}.
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The NS MMQ 3-site linear model has the parameters {{{:R2zero}}, ..., {{:pA}}, {{:pB}}, {{:DeltaomegaAB}}, {{:DeltaomegaBC}}, {{:DeltaomegaHAB}}, {{:DeltaomegaHBC}}, {{:kexAB}}, {{:kexBC}}}.
  
 
== Reference ==
 
== Reference ==
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The references for the NS MMQ 3-site linear model are:
 
The references for the NS MMQ 3-site linear model are:
  
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* Korzhnev, D. M., Kloiber, K., Kanelis, V., Tugarinov, V., and Kay, L. E. (2004).  Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme. ''J. Am. Chem. Soc.'', '''126'''(12), 3964-3973. ([http://dx.doi.org/10.1021/ja039587i 10.1021/ja039587i]).
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* {{#lst:Citations|Korzhnev04a}}
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* Korzhnev, D. M., Kloiber, K., and Kay, L. E. (2004).  Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application. ''J. Am. Chem. Soc.'', '''126'''(23), 7320-7329. ([http://dx.doi.org/10.1021/ja049968b 10.1021/ja049968b]).
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* Korzhnev, D. M., Neudecker, P., Mittermaier, A., Orekhov, V. Y., and Kay, L. E. (2005).  Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant. ''J. Am. Chem. Soc.'', '''127'''(44), 15602-15611. ([http://dx.doi.org/10.1021/ja054550e 10.1021/ja054550e]).
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* {{#lst:Citations|Korzhnev04b}}
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* {{#lst:Citations|Korzhnev05a}}
  
 
== Links ==
 
== Links ==
  
 
The [[Relaxation dispersion citation for relax|implementation of the NS MMQ 3-site linear model in relax]] can be seen in the:
 
The [[Relaxation dispersion citation for relax|implementation of the NS MMQ 3-site linear model in relax]] can be seen in the:
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* [http://www.nmr-relax.com/manual/NS_MMQ_3_site_linear_model.html relax manual],  
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* [http://www.nmr-relax.com/manual/The_NS_MMQ_3_site_linear_model.html relax manual],  
 
* [http://www.nmr-relax.com/api/3.1/lib.dispersion.ns_mmq_3site-module.html API documentation],
 
* [http://www.nmr-relax.com/api/3.1/lib.dispersion.ns_mmq_3site-module.html API documentation],
 
* [http://www.nmr-relax.com/analyses/relaxation_dispersion.html#NS_MMQ_3-site_linear relaxation dispersion page of the relax website].
 
* [http://www.nmr-relax.com/analyses/relaxation_dispersion.html#NS_MMQ_3-site_linear relaxation dispersion page of the relax website].
  
 
== See also ==
 
== See also ==
 +
[[Category:Models]]
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[[Category:Dispersion models]]
 
[[Category:MMQ CPMG data]]
 
[[Category:MMQ CPMG data]]
 
[[Category:Relaxation dispersion analysis]]
 
[[Category:Relaxation dispersion analysis]]

Latest revision as of 16:47, 6 November 2015

The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for MMQ CPMG-type data linearised with kAC = kCA = 0 whereby the simplification R2A0 = R2B0 = R2C0 is assumed.

Parameters

The NS MMQ 3-site linear model has the parameters {R20, ..., pA, pB, ΔωAB, ΔωBC, ΔωHAB, ΔωHBC, kexAB, kexBC}.

Reference

The references for the NS MMQ 3-site linear model are:

  • Korzhnev, D. M., Kloiber, K., Kanelis, V., Tugarinov, V., and Kay, L. E. (2004). Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme. J. Am. Chem. Soc., 126(12), 3964-3973. (DOI: 10.1021/ja039587i)
  • Korzhnev, D. M., Kloiber, K., and Kay, L. E. (2004). Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application. J. Am. Chem. Soc., 126(23), 7320-7329. (DOI: 10.1021/ja049968b)
  • Korzhnev, D. M., Neudecker, P., Mittermaier, A., Orekhov, V. Y., and Kay, L. E. (2005). Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant. J. Am. Chem. Soc., 127(44), 15602-15611. (DOI: 10.1021/ja054550e)

Links

The implementation of the NS MMQ 3-site linear model in relax can be seen in the:

See also

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