TSMFK01

This is the model for 2-site very-slow exchange model for time scales within range of microsecond to second time scale, where p_A ≫ p_B, and named after Tollinger et al. (2001). This model is labelled as TSMFK01 in relax. A particularly interesting feature of the dispersion curves is the damped oscillations, which occur at low CPMG field strengths, and is solely a function of the chemical shift difference between the two sites (i.e., independent of the rate of exchange).

Parameters

The TSMFK01 model has the parameters {R_2A⁰, ..., Δω, k_AB}.

Reference

The reference for the TSMFK01 model is:

• Tollinger, M., Skrynnikov, N. R., Mulder, F. A. A., Forman-Kay, J. D., and Kay, L. E. (2001). Slow dynamics in folded and unfolded states of an sh3 domain. J. Am. Chem. Soc., 123(46), 11341-11352. (DOI: 10.1021/ja011300z)

Links

The implementation of the TSMFK01 model in relax can be seen in the:

• relax manual,
• API documentation,
• relaxation dispersion page of the relax website.