Difference between revisions of "NS MMQ 3-site"

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The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for [[:Category:MMQ CPMG data|MMQ CPMG-type data]] whereby the simplification $R^0_{2A} = R^0_{2B} = R^0_{2C}$ is assumed.
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The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for [[:Category:MMQ CPMG data|MMQ CPMG-type data]] whereby the simplification {{:R2Azero}} = {{:R2Bzero}} = {{:R2Czero}} is assumed.
  
 
== Parameters ==
 
== Parameters ==
  
The NS MMQ 3-site model has the parameters {$R_2^0$, $...$, $p_A$, $p_B$, $\Delta\omega_{AB}$, $\Delta\omega_{BC}$, $\Delta\omega^H_{AB}$, $\Delta\omega^H_{BC}$, $k_{ex}^{AB}$, $k_{ex}^{BC}$, $k_{ex}^{AC}$}.
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The NS MMQ 3-site model has the parameters {{{:R2zero}}, ..., {{:pA}}, {{:pB}}, {{:DeltaomegaAB}}, {{:DeltaomegaBC}}, {{:DeltaomegaHAB}}, {{:DeltaomegaHBC}}, {{:kexAB}}, {{:kexBC}}, {{:kexAC}}}.
  
 
== Reference ==
 
== Reference ==

Revision as of 17:06, 22 October 2015

The 3-site relaxation dispersion model for the numeric solution (NS) to the Bloch-McConnell equations for MMQ CPMG-type data whereby the simplification R2A0 = R2B0 = R2C0 is assumed.

Parameters

The NS MMQ 3-site model has the parameters {R20, ..., pA, pB, ΔωAB, ΔωBC, ΔωHAB, ΔωHBC, kexAB, kexBC, kexAC}.

Reference

The references for the NS MMQ 3-site model are:

  • Korzhnev, D. M., Kloiber, K., Kanelis, V., Tugarinov, V., and Kay, L. E. (2004). Probing slow dynamics in high molecular weight proteins by methyl-TROSY NMR spectroscopy: application to a 723-residue enzyme. J. Am. Chem. Soc., 126(12), 3964-3973. (10.1021/ja039587i).
  • Korzhnev, D. M., Kloiber, K., and Kay, L. E. (2004). Multiple-quantum relaxation dispersion NMR spectroscopy probing millisecond time-scale dynamics in proteins: theory and application. J. Am. Chem. Soc., 126(23), 7320-7329. (10.1021/ja049968b).
  • Korzhnev, D. M., Neudecker, P., Mittermaier, A., Orekhov, V. Y., and Kay, L. E. (2005). Multiple-site exchange in proteins studied with a suite of six NMR relaxation dispersion experiments: an application to the folding of a Fyn SH3 domain mutant. J. Am. Chem. Soc., 127(44), 15602-15611. (10.1021/ja054550e).

Links

The implementation of the NS MMQ 3-site model in relax can be seen in the:

See also