This is the model for 2-site very-slow exchange model for time scales within range of microsecond to second time scale, where p<sub>A</sub> >> p<sub>B</sub>$p_A \gg p_B$, and named after Tollinger et al. (2001). It This model is selected by setting the model to labelled as '''TSMFK01''' in relax. A particularly interesting feature of the dispersion curves is the damped oscillations, which occur at low CPMG field strengths, and is solely a function of the chemical shift difference between the two sites (i.e., independent of the rate of exchange). The reference is:
* Tollinger, M., Skrynnikov, N. R., Mulder, F. A. A., Forman-Kay, J. D., and Kay, L. E. (2001). Slow dynamics in folded and unfolded states of an sh3 domain. ''J. Am. Chem. Soc.'', '''123'''(46), 11341–11352. ([http://dx.doi.org/10.1021/ja011300z doi: 10.1021/ja011300z])== Parameters ==
The TSMFK01 model has the parameters {$R_{2A}^0$, $...$, $\Delta\omega$, $k_{AB}$}.
== Reference ==
The reference for the TSMFK01 model is:
* Tollinger, M., Skrynnikov, N. R., Mulder, F. A. A., Forman-Kay, J. D., and Kay, L. E. (2001). Slow dynamics in folded and unfolded states of an sh3 domain. ''J. Am. Chem. Soc.'', '''123'''(46), 11341-11352. ([http://dx.doi.org/10.1021/ja011300z 10.1021/ja011300z])
== Links ==
The implementation of the TSMFK01 model in relax can be seen in the:
* [http://www.nmr-relax.com/manual/TSMFK01_2_site_CPMG_model.html relax manual],
* [http://www.nmr-relax.com/api/3.1/lib.dispersion.tsmfk01-module.html API documentation],
* [http://www.nmr-relax.com/analyses/relaxation_dispersion.html relaxation dispersion page of the relax website].
== See also ==
[[Category:Relaxation_dispersion]]